The Royal Manchester Children's Hospital is the largest children's ward in the UK. It sees up to 16,000 patients, even over Christmas. We find out what's happened to the amazing kids who starred in last year's festive Christmas series. We remember the fun, presents and hospital Santas, and catch up with the story of a newly born boy treated for a life threatening tumour operation, update an extraordinary girl's courageous kidney transplant operation and find out if an amazing seven year old's experimental drugs trial actually worked. Will it be another Xmas stay in hospital for some of our kids whose stories meant so much last year?